Extracellular vesicle development and manufacturing -both GMP and non-GMP
Stockholm, Sweden · NorthX Biologics
Quick answer
This service in Stockholm, Sweden provides for Drug formulation, Analytical chemistry, Structural biology, Cell biology, Medical devices, Neuroscience, Clinical research, Regenerative medicine, Immunology. Reference price: 75,000 to 200,000 SEK per project.
Capabilities
Flexible platforms for complex products Extracellular vesicles (EV) such as exosomes are becoming an attractive new therapeutic modality for both immunotherapy and as vectors for various cargos such as nucleic acids and proteins, representing a major advancement in drug delivery and biologics. EVs offers a natural and highly adaptable platform for vaccines and delivery vehicles. Being complex structures with an inherent heterogeneity, manufacturing for clinical stage requires special attention. Building on our long track record from development and manufacturing of biologicals we ensure the flexibility to meet the special requirements of these highly complex products. EVs origin from animal derived or human cell lines are nanosized vesicles that play a critical role in intercellular communication by transferring proteins, lipids, and nucleic acids between cells. Cell types used for therapeutic EV production include: Mesenchymal stem cells (MSC) Dendritic cells (DC) Various immune cells We offer a full range of culture systems spanning from T-flasks to Icellis500 fixed bed bioreactor for seamless scale up. For suspension culture, we offer solutions up to 250L culture volume. Isolation and purification are done using advanced technologies, to ensure high-purity EV products suitable for therapeutic applications. Our in-house analytics ensure full control and rapid timelines. Technologies include: Dynamic light scattering (DLS) Flow cytometry (FACS) dPCR/qPCR Capillary Electrophoresis (CE) HPLC ELISA We also conduct stability studies to monitor drug substance and product integrity, with thorough documentation and transparency throughout the process.
Location & contact
Reference pricing
| Type | Service |
|---|---|
| Technique | N/A |
| Research areas | Drug formulation, Analytical chemistry, Structural biology, Cell biology, Medical devices, Neuroscience, Clinical research, Regenerative medicine, Immunology |
| ISO / certificates | GMP certified |
| City | Stockholm |
| Country | Sweden |
| Provider | NorthX Biologics |
| Reference price | 75,000 to 200,000 SEK / project |
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